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Mutation rate and spectrum in endogenous Ramos B cells VH4-DXP′1-JH6 and transfected VH1-DXP′1-JH5 gene segments. The number and nature of independent mutations scored in the endogenous VH4-DXP’1-JH6 or VH 1-DXP′1-JH5 from transfected contructs, as indicated at the bottom, are depicted in the upper squares. Tabulated are mutation rate, the ratio of mutations at dC/dG vs. at dA/dT, and the ratio of transitions vs. transversions at both dA/dT and dC/dG mutations.
