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. 2015 Oct 14;172(20):4959–4969. doi: 10.1111/bph.13265

Figure 4.

Figure 4

Acute angiotensin (ANG) II stimulation alters the A1 receptor‐ and CYP4A‐dependent NECA‐induced responses in MAs from WT mice. Pre‐incubation of MAs with the A1 receptor antagonist DPCPX 1 μM (Control n = 10, DPCPX n= 6) (A) and CYP4A inhibitor HET0016 10 μM (Control n = 7, HET0016 n = 7) (B) significantly inhibited ANG II‐induced (10 nM) vasoconstrictions. (C) ANG II‐induced altered responses to NECA were blocked by DPCPX and HET0016. * P < 0.05 compared with control, and # P < 0.05 compared with ANG II‐stimulated response.