Table 6.

Effect of CBD on arrestin2 recruitment to mutant CB₁ receptors in STHdh ^Q7/Q7 cells

Agonist	Receptor	Modulator	EC50 μM (95% CI)	E max (95% CI)
THC	CB1 WT	DMSO	0.34 (0.21–0.46)	0.96 (0.75–1.01)
		5.00 μM CBD	0.91 (0.70–1.17)†	0.30 (0.24–0.49)†
	CB1 C98A	DMSO	0.35 (0.26–0.57)	0.94 (0.78–1.11)
		5.00 μM CBD	0.55 (0.37–0.67)^	0.64 (0.54–0.74)^, †
	CB1 C107A	DMSO	0.36 (0.23–0.46)	0.94 (0.82–1.07)
		5.00 μM CBD	0.56 (0.48–0.67)^, †	0.61 (0.54–0.73)^, †
	CB1 C98S	DMSO	0.30 (0.17–0.41)	0.98 (0.83–1.12)
		5.00 μM CBD	0.97 (0.79–1.10)†	0.37 (0.32–0.42)†
	CB1 C107S	DMSO	0.31 (0.16–0.48)	1.00 (0.82–1.18)
		5.00 μM CBD	0.91 (0.80–1.02)†	0.36 (0.31–0.41)†
2‐AG	CB1 WT	DMSO	0.64 (0.56–0.73)	0.82 (0.74–0.90)
		5.00 μM CBD	2.20 (1.95–3.55)†	0.44 (0.25–0.57)†
	CB1 C98A	DMSO	0.62 (0.54–0.78)	0.96 (0.84–1.09)
		5.00 μM CBD	1.37 (1.09–1.59)^, †	0.67 (0.59–0.71)^, †
	CB1 C107A	DMSO	0.59 (0.43–0.69)	1.03 (0.89–1.18)
		5.00 μM CBD	1.42 (1.23–1.64)^, †	0.66 (0.58–0.72)^, †
	CB1 C98S	DMSO	0.68 (0.59–0.74)	1.01 (0.90–1.12)
		5.00 μM CBD	2.32 (1.97–2.57)†	0.37 (0.24–0.50)†
	CB1 C107S	DMSO	0.67 (0.59–0.79)	1.00 (0.90–1.11)
		5.00 μM CBD	2.28 (2.14–2.40)†	0.38 (0.24–0.52)†

CI, confidence interval.

Data shown are means with 95% CI, from four independent experiments.

^{^} Significantly different from response to 5.00 μM CBD and DMSO vehicle in CB₁ ^WT vehicle as determined by non‐overlapping CI.

^† Significantly different from DMSO vehicle within receptor group as determined by non‐overlapping CI.