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. 2015 Oct 8;172(20):4806–4816. doi: 10.1111/bph.13251

Figure 1.

Figure 1

Comparison of the PK/PD relationship between ex vivo activity of the human 11β‐HSD1 enzyme in sub‐cutaneous AT biopsies (measured as the conversion of 3H‐cortisone to 3H‐cortisol) and free plasma concentrations of AZD8329 both after acute and repeat oral administration (n = 6 per dose level). A direct response (Emax) model was used to fit the PK/PD results. The observed results for day 1 and for day 9 are shown with the corresponding lines representing the model fit for each set of observations.