Figure 4.

Mouse experiment with COMPOUND‐20: (A) Box and whisker plot of ex vivo activity of mouse 11β‐HSD1 enzyme in epididymal AT (measured conversion of ³H‐cortisone to ³H‐cortisol) after acute and repeat oral administration, per treatment group of COMPOUND‐20 (n = 13), comparison of the vehicle (n = 5) versus the treated groups (see legend of Figure 3 for description of box and whiskers plot). ***P < 0.001, significantly different from vehicle . (B) Comparison of the PK/PD relationship between mouse 11β‐HSD1 enzyme activity and free plasma concentrations of COMPOUND‐20 after acute and repeat (b.i.d. or u.i.d. for 7 days) oral administration in mice. (C) Treatment groups statistical comparison of the ex vivo activity of the mouse 11β‐HSD1 enzyme in epididymal AT. The confidence intervals are 95% (with Sidak's multiple comparison adjustment) so statistical significance was inferred if the 95% confidence interval did not span zero. *P < 0.05.