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. 2015 Oct 8;172(20):4806–4816. doi: 10.1111/bph.13251

Table 1.

PK/PD parameters for model fit for AZD8329 in the ex vivo human adipose tissue 11β‐HSD1 activity assay after acute and repeat oral administration in humans

Day Parameter Estimate Units %CV
Day 1 IC50 0.022 μM 23
E0 9.9 %conv per 100 mg 9.2
Day 9 IC50 0.144 μM 37
E0 8.0 %conv per 100 mg 13