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PK/PD parameters for model fit for AZD8329 in the ex vivo 11β‐HSD1 activity assay in rat AT, after an acute and repeat oral administration
| Day | Parameter | Estimate | Units | %CV |
|---|---|---|---|---|
| Acute | E0 | 102 | – | 3.9 |
| IC50 | 0.10 | μM | 33 | |
| Emax | 10.0 | – | 55 | |
| Repeat | E0 | 104 | – | 5.6 |
| IC50 | 1.24 | μM | 33 | |
| Emax | 10.0 | – | FIXED |
