Figure 3.

(A) Glycaemia and (B) insulinaemia in fasted and 2 h refed diet‐induced obese (DIO) mice treated or not with citrulline (cit) and atorvastatin (stat) and in control lean mice. (C) phosphoenolpyruvate carboxykinase (PEPCK) gene expression in liver of fasted and 2 h refed DIO mice treated or not with citrulline (cit) and/or atorvastatin (stat) and in control lean mice. (D) Impact of citrulline, atorvastatin and combination of the two on insulin‐induced changes in phospho(Ser⁴⁷³)‐Akt/total Akt in human HuH7 hepatocarcinoma cells and (E) related Western blot images. For A–C: * P < 0.05, significantly different from controls; ^# P < 0.05, significantly different fasted conditions; ^$ P < 0.05, significantly different from control and DIO groups. For D: *P < 0.05, significantly different from controls and citrulline–atorvastatin combination; ^$ P < 0.05, significantly different from citrulline–atorvastatin combination. HPRT, hypoxanthine guanine phosphoribosyl transferase.