Table 4.
Control | DIO | DIOcit–stat | DIOstat | DIOcit | |
---|---|---|---|---|---|
Lxrα | 0.95 ± 0.14 | 1.37 ± 0.13* | 0.61 ± 0.08$ | 1.26 ± 0.11 | 1.08 ± 0.12 |
Chrebp | 0.98 ± 0.15 | 1.73 ± 0.26* | 0.99 ± 0.15 | 1.68 ± 0.19* | 1.72 ± 0.17* |
PPAR α | 0.92 ± 0.09 | 1.32 ± 0.15 | 0.67 ± 0.10* | 0.78 ± 0.10* | 1.41 ± 0.18 |
Pgc‐1α | 1.37 ± 0.20 | 1.02 ± 0.12* | 0.98 ± 0.08* | 0.81 ± 0.07* | 1.55 ± 0.25 |
PPAR γ | 0.73 ± 0.09 | 1.31 ± 0.27* | 0.60 ± 0.06# | 1.08 ± 0.11 | 1.16 ± 0.11* |
Acc1 | 1.07 ± 0.10 | 0.92 ± 0.08* | 0.68 ± 0.03$ | 1.41 ± 0.14 | 1.29 ± 0.07 |
Fasn | 1.83 ± 0.24 | 1.21 ± 0.10* | 0.71 ± 0.06$ | 1.18 ± 0.11* | 1.14 ± 0.08* |
Scd1 | 1.64 ± 0.21 | 1.80 ± 0.44 | 0.36 ± 0.03$ | 0.86 ± 0.14 | 1.02 ± 0.13 |
Gpam | 1.13 ± 0.11 | 1.14 ± 0.12 | 1.02 ± 0.16 | 1.15 ± 0.11 | 1.23 ± 0.07 |
eNOS | 1.60 ± 0.21 | 1.14 ± 0.11* | 0.96 ± 0.09* | 0.91 ± 0.12* | 0.99 ± 0.10* |
Pgc‐1α, peroxisome proliferator‐activated receptor gamma coactivator 1‐α.
Results are expressed relative to Hprt gene expression (mean ± SEM, n = 10 per group). Dietary interventions: standard diet (control), high fat–high sucrose diet (DIO) and DIO enriched in citrulline (2.5 g∙kg−1) (DIOcit), atorvastatin (10 mg∙kg−1) (DIOstat) or citrulline and atorvastatin (DIOcit–stat).
P < 0.05, significantly different from controls;
P < 0.05, significantly different from control and other DIO groups.
P < 0.05, significantly different from other DIO groups.