Table 1.
Hill equation parameters for concentration‐response relationships for GABA‐evoked currents through native and recombinant GABAA receptors in the presence of either solvent or 30 μM flupirtine
| Solvent | Flupirtine (30 μM) | |||
|---|---|---|---|---|
| Receptor | EC50 (μM) | Emax (normalized) | EC50 (μM) | Emax (normalized) |
| Hippocampus | 9.4 ± 1.0 | 1.33 ± 0.03 | 3.5 ± 0.5*** | 1.25 ± 0.04 n.s. |
| Hippocampus (penicillin) | 1.8 ± 0.2 | 1.02 ± 0.02 | 1.2 ± 0.1*** | 1.46 ± 0.03*** |
| α1β2 | 0.8 ± 0.1 | 1.10 ± 0.02 | 0.3 ± 0.2** | 0.71 ± 0.02*** |
| α1β2γ2S | 3.0 ± 0.3 | 1.15 ± 0.02 | 1.1 ± 0.2*** | 0.85 ± 0.02*** |
| α1β2δ | 2.1 ± 0.2 | 1.11 ± 0.02 | 1.7 ± 0.2 n.s. | 2.27 ± 0.06*** |
| α2β2γ2S | 66.6 ± 18.4 | 3.03 ± 0.20 | 24.6 ± 6.4* | 2.54 ± 0.14 n.s. |
| α3β3γ2S | 27.0 ± 6.2 | 2.00 ± 0.10 | 7.4 ± 2.1** | 1.93 ± 0.10 n.s. |
| α4β3 | 0.2 ± 0.1 | 1.05 ± 0.02 | 0.2 ± 0.01 n.s. | 0.78 ± 0.02*** |
| α4β3γ2S | 28.0 ± 3.2 | 1.97 ± 0.07 | 7.0 ± 1.0*** | 1.63 ± 0.05*** |
| α4β3δ | 1.0 ± 0.02 | 1.10 ± 0.05 | 0.8 ± 0.02 n.s. | 1.55 ± 0.06*** |
| α5β3γ2S | 7.2 ± 1.2 | 1.25 ± 0.04 | 2.3 ± 1.0** | 0.94 ± 0.06*** |
Concentration‐response curves of currents through the GABAA receptors listed were obtained in the presence of either solvent or 30 μM flupirtine (F test; n = 4 − 8; n.s. = no significant difference).
*
P < 0.05.
**
P < 0.01.