Table 2.
Comparison of CTC numbers quantified with CellSearch® and filter-based CTC isolation (FMSA)
| Incision | During resection | 30 min after resection | Postoperative day 1 | Comparison of timepoints: P value2 | |
|---|---|---|---|---|---|
| CellSearch® | |||||
| Samples analyzed (total 92/100 possible) | 24 | 23 | 22 | 23 | |
| CTCs present (%) | 3 (12.5%) | 6 (26.1%) | 8 (36.4%) | 2 (8.7%) | |
| Mean (SEM) | 0.42 (±0.33) | 0.87 (±0.44) | 0.41 (±0.13) | 0.09 (±0.06) | 0.3018 |
| Median (Range) | 0 (0–8) | 0 (0–9) | 0 (0–2) | 0 (0–1) | |
| Filter-based CTC isolation (FMSA) | |||||
| Samples analyzed (total 65/100 possible) | 16 | 16 | 16 | 17 | |
| CTCs present (%) | 15 (93.4%) | 15 (93.4%) | 11 (68.8%) | 15 (88.2%) | |
| Mean (SEM) | 5.06 (±1.47) | 22.56 (±7.48) | 7.00 (±3.23) | 10.65 (±2.77) | 0.0281 |
| Median (Range) | 3 (0–19) | 8 (0–101) | 4 (0–53) | 6 (0–38) | |
| Comparison of CellSearch® vs. FMSA: P value1 | 0.0002 | 0.0001 | 0.0078 | 0.0001 |
SEM: standard error of the mean; FMSA: flexible micro spring array.
1
Wilcoxon Signed-rank test for matched pairs (non-parametric).
2
Repeated-measures ANOVA model.