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. 2015 Aug 10;33(31):3568–3575. doi: 10.1200/JCO.2015.60.9487

Table 2.

Comparison of Cumulative Incidence of SNs After 40 Years of Age on the Basis of History of SN Before 40 Years of Age

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Cancer and Age, Years Survivors ≥ 40 Years of Age
Patients at Risk
All
SN Before Age 40 Years
No SN Before Age 40 Years
No. % 95% CI No. % 95% CI No. % 95% CI
All SNs
    40 3,171 0 470 0 2,701 0
    45 1,190 12.1 10.7 to 13.5 150 27.4 22.3 to 32.6 1,040 9.4 8.0 to 10.8
    50 278 23.3 20.6 to 26.0 28 48.2 40.1 to 56.3 250 18.7 16.0 to 21.5
    55 26 34.6 28.7 to 40.6 5 57.6 46.7 to 68.6 21 30.4 23.8 to 37.0
Subsequent malignant neoplasm
    40 3,171 0 470 0 2,701 0
    45 1,307 4.8 3.9 to 5.8 196 7.7 4.6 to 10.8 1,111 4.3 3.4 to 5.3
    50 338 10.4 8.5 to 12.2 50 16.4 10.5 to 22.3 288 9.2 7.3 to 11.2
    55 42 16.3 11.7. to 20.9 8 20.8 12.5 to 29.1 34 15.4 10.2 to 20.5
Nonmelanoma skin cancer
    40 3,171 0 470 0 2,701 0
    45 1,260 6.8 5.7 to 7.9 169 19.1 14.7 to 23.6 1,092 4.6 3.6 to 5.6
    50 310 12.2 10.1 to 14.2 34 30.9 23.6 to 38.1 276 8.8 6.8 to 10.8
    55 37 19.6 14.7 to 24.5 6 38.2 27.9 to 48.5 31 16.2 10.8 to 21.6
Meningioma
    40 3,171 0 470 0 2,701 0
    45 1,368 0.4 0.2 to 0.7 212 1.1 0.0 to 2.2 1,156 0.3 0.1 to 0.6
    50 369 1.2 0.4 to 1.9 60 1.1 0.0 to 2.2 309 1.2 0.3 to 2.0
    55 53 1.4 0.5 to 2.4 8 2.8 0.0 to 6.3 45 1.2 0.3 to 2.0

Abbreviation: SN, subsequent neoplasm.