Table 1.
Characteristics of RB Survivors and CCSS Siblings
| Characteristic | All RB Survivors (n = 470) | Unilateral RB (n = 218) | Bilateral RB (n = 252) | CCSS Siblings (n = 2,820) | P* | P† |
|---|---|---|---|---|---|---|
| Age at diagnosis, median (range), years | 1 (0-17) | 2 (0-17) | 1 (0-8) | NA | < .01 | NA |
| Age at study, mean (standard deviation), years | 43.3 (11) | 44.4 (11) | 42.5 (10.8) | 33 (18-58) | .08 | < .01 |
| Sex | .23 | .57 | ||||
| Female | 245 (52.1) | 120 (55.1) | 125 (49.6) | 1,510 (53.6) | ||
| Male | 225 (47.9) | 98 (44.9) | 127 (50.4) | 1,310 (46.4) | ||
| Race/ethnicity | .37 | < .01 | ||||
| White, non-Hispanic | 406 (86.4) | 185 (84.8) | 221 (87.7) | 2,492 (88.4) | ||
| Others | 62 (13.2) | 32 (14.7) | 30 (11.9) | 226 (8.0) | ||
| Unknown | 2 (0.4) | 1 (0.5) | 1 (0.4) | 102 (3.6) | ||
| Marital status | .03 | .66 | ||||
| Single | 142 (30.2) | 53 (24.3) | 39 (35.3) | 853 (30.3) | ||
| Married or living with a partner as married | 272 (57.9) | 136 (62.4) | 136 (54.0) | 1,695 (60.1) | ||
| Widowed/divorced/separated | 48 (10.2) | 25 (11.5) | 23 (9.1) | 257 (9.1) | ||
| Unknown | 8 (1.7) | 4 (1.8) | 4 (1.6) | 15 (0.5) | ||
| Family history of RB | < .01 | NA | ||||
| Yes | 92 (20.0) | 14 (6.4) | 78 (31.0) | NA | ||
| No | 323 (69.0) | 175 (80.3) | 148 (58.7) | NA | ||
| Unknown | 55 (11.0) | 29 (13.3) | 26 (10.3) | NA | ||
| Education | .63 | .56 | ||||
| Completed high school or less | 64 (13.6) | 28 (12.8) | 36 (14.3) | 422 (15.0) | ||
| Post high school or some college training | 394 (83.8) | 185 (84.9) | 209 (83.0) | 2,389 (84.7) | ||
| Unknown/missing | 12 (2.6) | 5 (2.3) | 7 (2.7) | 9 (0.3) | ||
| Learning disabled/special education program | < .01 | NA | ||||
| Yes | 76 (16.2) | 17 (7.8) | 59 (23.4) | NA | ||
| No | 380 (80.9) | 196 (89.9) | 184 (73.0) | NA | ||
| Unknown/missing | 14 (2.9) | 5 (2.2) | 9 (3.6) | NA | ||
| Current employment status | < .01 | < .01 | ||||
| Never had a job | 7 (1.5) | 2 (0.9) | 5 (2.0) | 29 (1.0) | ||
| Currently working full- or part-time | 346 (73.6) | 175 (80.3) | 171 (67.9) | 2,372 (84.1) | ||
| Not currently working | 94 (20.0) | 30 (13.8) | 64 (25.4) | 419 (14.9) | ||
| Unknown/missing | 23 (4.9) | 11 (5.0) | 12 (4.7) | 0 | ||
| Household income, $ | .016 | .03 | ||||
| < 20,000 | 45 (9.6) | 13 (6.0) | 32 (12.7) | 188 (6.7) | ||
| ≥ 20,000 | 392 (83.4) | 187 (85.7) | 205 (81.4) | 2,344 (83.1) | ||
| Unknown/missing | 33 (7.0) | 18 (8.3) | 15 (5.9) | 288 (10.2) | ||
| Health insurance | .24 | .52 | ||||
| Currently has health insurance | 416 (88.5) | 188 (86.2) | 228 (90.5) | 2,536 (90.0) | ||
| Currently does not have health insurance | 52 (11.1) | 29 (13.3) | 23 (9.1) | 273 (9.7) | ||
| Unknown/missing | 2 (0.4) | 1 (0.5) | 1 (0.4) | 11 (0.3) | ||
| Radiation therapy | < .01 | NA | ||||
| Yes | 265 (56.4) | 34 (15.6) | 231 (91.7) | NA | ||
| No | 200 (43.6) | 180 (82.6) | 20 (7.9) | NA | ||
| Unknown/missing | 5 (1.0) | 4 (1.8) | 1 (0.4) | NA | ||
| Chemotherapy | < .01 | NA | ||||
| Yes | 119 (25.3) | 25 (11.5) | 94 (37.3) | NA | ||
| No | 347 (73.8) | 190 (87.2) | 157 (62.3) | NA | ||
| Unknown/missing | 4 (0.9) | 3 (1.3) | 1 (0.4) | NA | ||
| Second malignant neoplasm | < .01 | NA | ||||
| Yes | 70 (15.0) | 14 (6.5) | 56 (22.5) | |||
| Surgery: enucleation | ||||||
| No | 54 (11.5) | 21 (9.6) | 33 (13.1) | NA | < .01 | NA |
| Both eyes | 54 (11.5) | 0 | 54 (21.4) | NA | ||
| One eye | 350 (74.5) | 190 (87.2) | 160 (63.5) | NA | ||
| Unknown/missing | 12 (2.5) | 7 (3.2) | 5 (2.0) | NA |
NOTE. Data are given as No. (%) unless otherwise indicated.
Abbreviations: CCSS, Childhood Cancer Survivor Study; NA, not applicable; RB, retinoblastoma.
*
P value comparing characteristic differences between unilateral and bilateral patients. Factors with missing values were excluded.
†
P value comparing characteristic differences between RB survivors (n = 470) and CCSS siblings (n = 2,820). Missing values were excluded.