FIG 4.

Antigen identities and T cell response frequencies for each experimental cohort. The frequencies of subjects responding to selected or described genes are compared to the frequencies of responses in individual cohorts. The frequency ranges are displayed as a blue-to-red heat map. The white squares indicate that the frequency of response against that antigen has failed to meet the selection threshold. The aggregate frequencies of responses to antigens associated with an effective or ineffective immune responses are shown, ordered in rank from high to low occurrence. (A and B) CD4⁺ (A) and CD8⁺ (B) T cell responses. (C and D) Same information for TFI, successful pregnancy, and naive cohorts for CD4⁺ (C) and CD8⁺ (D). (E and F) Frequency distribution of a select group of antigens previously described in the literature as immunodominant or potentially immunoprotective for all cohorts for CD4⁺ (E) and CD8⁺ (F). All standardized C. trachomatis gene identifiers, along with colloquial gene names, when available, are provided.