TABLE 4.
Line immunoblotting of serum samples
| Category (na) | No. of positive reactions (%) |
||||
|---|---|---|---|---|---|
| IgM |
IgG |
||||
| rBBA65 | rBBA70 | rBBA73 | rBBA69 | rBBA73 | |
| Lyme disease | |||||
| Early Lyme disease with EM | |||||
| Acute phase (23) | 7 (30) | 5 (22) | 6 (26) | 2 (9) | 4 (17) |
| Convalescent phase (23) | 9 (39) | 8 (35) | 11 (48) | 2 (9) | 6 (26) |
| Lyme neuroborreliosis (10) | 7 (70) | 3 (30) | 5 (50) | 2 (20) | 3 (30) |
| Lyme carditis (6) | 2 (33) | 2 (33) | 1 (17) | 2 (33) | 1 (17) |
| Late Lyme diseases (Lyme arthritis) (8) | 1 (13) | 1 (13) | 0 (0) | 2 (25) | 4 (50) |
| Total early Lyme disease (62) | 25 (40) | 18 (29) | 23 (37) | 8 (13) | 14 (23) |
| Total Lyme disease (70) | 26 (37) | 19 (27) | 23 (33) | 10 (14) | 18 (26) |
| Other diseases | |||||
| Fibromyalgia (8) | 2 (25) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Rheumatoid arthritis (8) | 2 (25) | 0 (0) | 0 (0) | 1 (13) | 1 (13) |
| Multiple sclerosis (8) | 2 (25) | 0 (0) | 0 (0) | 1 (13) | 1 (13) |
| Mononucleosis (8) | 6 (75) | 0 (0) | 5 (63) | 0 (0) | 1 (13) |
| Syphilis (8) | 0 (0) | 0 (0) | 0 (0) | 1 (13) | 3 (38) |
| Severe periodontitis (8) | 1 (13) | 0 (0) | 0 (0) | 1 (13) | 0 (0) |
| Healthy controls | |||||
| Healthy; endemic (16) | 1 (6) | 0 (0) | 3 (19) | 1 (6) | 3 (19) |
| Healthy; nonendemic (16) | 2 (13) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Total non-Lyme disease (80) | 18 (23) | 0 (0) | 8 (10) | 5 (6) | 9 (11) |
| Lyme patient samples 2-tier-test negative (n = 23) but reactive with test antigens | 4 (17) | 1 (4) | 2 (9) | 3 (13) | 2 (9) |
a
n, number of samples. “Endemic” and “nonendemic” refer to samples from patients in areas where Lyme disease is and is not endemic, respectively.