TABLE 2.
Diagnostic performance of tryparedoxin peroxidase, eukaryotic initiation factor 5a, enolase, β-tubulin, and recombinant hypothetical protein, as well as L. braziliensis SLA for serodiagnosis of TL
| Antigen | Cutoff valuea | % sensitivity (95% CI) | % specificity (95% CI) | AUC (95% CI) | % AC |
|---|---|---|---|---|---|
| Tryparedoxin peroxidase | 0.374 | 100 (91.8–100) | 100 (91.2–100) | 1.0 (1.0–1.0) | 100 |
| Eukaryotic initiation factor 5a | 0.100 | 100 (91.8–100) | 92.5 (79.6–98.4) | 1.0 (0.9–1.0) | 96.4 |
| Enolase | 0.045 | 100 (91.8–100) | 85.0 (70.2–94.3) | 0.9 (0.9–1.0) | 92.8 |
| β-Tubulin | 0.081 | 100 (91.0–100) | 82.5 (67.2–92.7) | 0.9 (0.9–1.0) | 91.6 |
| Hypothetical protein | 0.089 | 95.4 (84.2–99.4) | 85.0 (70.2–94.3) | 1.0 (0.9–1.0) | 90.4 |
| L. braziliensis SLA | 0.743 | 65.1 (49.1–79.0) | 57.5 (40.9–73.0) | 0.6 (0.5–0.7) | 61.4 |
a
The cutoff values were obtained using the ROC curves, as well as the sensitivity, specificity, accuracy (AC) and area under the curve (AUC).