Temporal course of Scale for the Assessment of Positive Symptoms (SAPS) (A), Scale for the Assessment of Negative Symptoms (SAPS) (B), Subjective Well-Being Under Neuroleptic Treatment Scale (SWN) (C) and Schizophrenia Quality of Life Scale (S-QoL) (D) during 30 months of long-acting risperidone treatment. Black circle are mean; vertical bars are standard error of the mean (SEM). Lowercase letters indicate p-value of Bonferroni post hoc test of a specified temporal condition respect to related baseline condition: a, p
< 0.05; b, p
< 0.01; c, p
< 0.001; d, p
< 0.0001.