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Diagnostic accuracy for detection of hepatocellular carcinoma using one or two markers.
| Markers | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | LR− |
|---|---|---|---|---|---|---|
| One marker | ||||||
| P53 | 50.9 | 98.9 | 98.2 | 62.2 | 46.3 | 0.50 |
| HSP70 | 78.2 | 77.8 | 81.1 | 74.5 | 3.53 | 0.28 |
| Two markers | ||||||
| Parallel | 95.5 | 85.5 | 89.0 | 93.9 | 6.6 | 0.05 |
| Serial | 33.6 | 98.9 | 97.4 | 54.9 | 30.27 | 0.67 |
PPV – positive predictive value; NPV – negative predictive value; LR – likelihood ratio. Parallel – at least 1 positive. Serial – both 2 positive.
