Table 2. Liver test results and virologic characteristics of 15 patients with hepatitis E virus–linked neurologic disorders, France, January 2006–June 2013*.
| Patient no. | Diagnosis | AST, IU/L | ALT, IU/L | Bilirubin, µmol/L | ALKP, IU/L | GGT, IU/L | PT, % | GT | Serology | Serum viral load, log-copies/mL | PCR stools | PCR CSF |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | MM | 69 | 256 | 8.6 | 254 | 323 | 92 | 3f | IgG+/IgM+ | 4.92 | NA | NA |
| 2 | MM | 507 | 756 | 17 | 540 | 187 | 90 | 3f | IgG+/IgM+ | 5 | Pos | NA |
| 3 | MM | NA | 3,641 | 90 | NA | NA | 80 | NA | IgG+/IgM+ | Neg | Neg | NA |
| 4 | MM | 54 | 120 | 10 | NA | 95 | 100 | NA | IgG+/IgM+ | Neg | Neg | NA |
| 5 | MM | 50 | 118 | 14 | 90 | 95 | 95 | NA | IgG+/IgM+ | Pos | NA | Neg |
| 6 | MM | 71 | 119 | 14 | 430 | 131 | 100 | 3f | IgG–/IgM+ | 5.57 | Pos | NA |
| 7 | PTS | 897 | 1,834 | 42 | 336 | 383 | 88 | NA | IgG+/IgM+ | 2.12 | NA | NA |
| 8 | PTS | 1.330 | 1,900 | 15 | 194 | 182 | 95 | NA | IgG+/IgM+ | 2.81 | NA | NA |
| 9 | PTS | 601 | 1,376 | 15 | 231 | 601 | 95 | NA | IgG+/IgM+ | NA | NA | NA |
| 10 | PTS | 135 | 495 | 17 | 659 | 740 | 100 | 3f | IgG+/IgM+ | 3.89 | Pos | NA |
| 11 | MR | 1.742 | 822 | 101 | 704 | 528 | 76 | 3f | IgG+/IgM+ | 5.83 | Pos | Pos |
| 12 | MR | 221 | 566 | 11 | 124 | 184 | 100 | NA | IgG+/IgM+ | Pos | NA | Pos |
| 13 | MR | 100 | 246 | 4.7 | 248 | 33 | 98 | 3f | IgG–/IgM+ | 2.9 | Pos | Neg |
| 14 | AIDP | 113 | 384 | 34.2 | 474 | 783 | 100 | 3f | IgG+/IgM+ | Pos | Pos | Neg |
| 15 | AIDP | 37 | 49 | 7 | 88 | 48 | 94 | NA | IgG+/IgM+ | Neg | Neg | Neg |
*AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALKP, alkaline phosphatase; GGT, γ-glutamyl transpeptidase; PT, prothrombin time; GT, genotype; CSF, cerebral spinal fluid; MM: mononeuritis multiplex, NA, not available; Pos, positive; Neg, negative; PTS: Parsonage-Turner syndrome; MR: meningoradiculitis; AIDP, acute inflammatory demyelinating polyradiculoneuropathy.