Figure 3.

Effect of TPI on trifluorothymidine (TFT) pharmacokinetics. Plasma TFT levels in mice (a) and monkeys (b) were measured following oral administration in the presence and absence of TPI. TFT (black circles) was administered in doses of 50 mg/kg (normal mice) or 10 mg/kg (normal monkeys), or in combination with an equimolar amount of TPI (white circles). Values are means of several experiments (n = six mice; n = three monkeys). (Data adapted from [Fukushima et al. 2000] with permission.)