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The neurovascular bundle niche and the in vivo origin of incisor mesenchymal stem cells. SHH is secreted by the sensory neurons in the trigeminal ganglion and transported through nerve axons into the incisor mesenchyme. SHH activates Gli1 expression in the stem cells surrounding the arterioles and regulates their differentiation. Gli1+ stem cells give rise to actively dividing transit amplifying cells and then differentiate into odontoblasts to support incisor mesenchyme turnover.
