Figure 3.

Sphingosine-1 phosphate lyase inhibition elevated the genes involved in stem cell survival and myocardial homing (n = 4 per time point per group). Bar graphs show significant upregulation of endothelial transcription factors VEGF and VE-cadherin and factors involved in stem cell homing such as SDF-1 and CXCR4 in peripheral blood cells at various time points after MI in vehicle-treated (n = 5) and THI-treated (n = 5) mice. Values are presented as mean ± SEM (∗, p < .05 compared with baseline values; #, p < .05 compared with vehicle controls and baseline values). Abbreviations: MI, myocardial infarction; PB, peripheral blood; SDF-1, stromal-derived factor 1; VE, vascular endothelial; VEGF, vascular endothelial growth factor.