OMLP-PCs demonstrate broad-spectrum antibacterial effects in coculture with bacteria. OMLP-PCs significantly reduced the growth of Gram-positive E. faecalis
(A) and S. pyogenes
(B) and Gram-negative P. aeruginosa
(C) and P. mirabilis
(D) bacteria. This effect was observed irrespective of OMLP-PCs prestimulation with IFN-γ or not. EFs had no effect on bacterial growth. Data are expressed as the percentage of growth ± SEM, with bacteria-only cultures set to 100%. ∗∗∗, p ≤ .001. Abbreviations: EFs, enriched fibroblasts; IFN-γ, interferon-γ; OMLP-PCs, oral mucosal lamina propria-progenitor cells.