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. 2015 Sep 16;4(11):1283–1293. doi: 10.5966/sctm.2015-0043

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Figure 4. — OPG demonstrated antibacterial properties against Gram-positive bacteria. OPG reduced the growth of Gram-positive bacteria E. faecalis (A) and S. pyogenes (B) only (no effect on Gram-negative bacteria [C, D]). Blocking OPG within the conditioned media of OMLP-PCs significantly restored the growth of Gram-positive E. faecalis (E) and S. pyogenes (F) bacteria. Data are expressed as the percentage of growth ± SEM, with bacteria-only cultures set to 100%. ∗, p ≤ .05; ∗∗, p ≤ .01; ∗∗∗, p ≤ .001. Abbreviations: EFs, enriched fibroblasts; IFN-γ, interferon-γ; OMLP-PCs, oral mucosal lamina propria-progenitor cells; OPG, osteoprotegerin.