Table 1.
Blocking monoclonal antibodies of TIM-1
| Clone | Host | Model | Effects | Ref. |
|---|---|---|---|---|
| 3B3 | C57BL/6 | Xenograft transplantation | Lymphocyte proliferation ↑ Tolerance ↓ | 21 |
| BALB/c | Ovalbumin-induced allergy | Lymphocyte proliferation ↑ IL-4, IL-10, IFN-γ production in CD4+ T cell ↑ |
22 | |
| BALB/c | Cardiac allograft | IL-17+ CD8+ T17 cell ↓ | 23 | |
| SJL | Autoimmune encephalomyelitis | Antigen specific T cell proliferation ↑ IL-4, IL-17, IFN-γ ↑ |
24 | |
| SJL | Autoimmune encephalomyelitis | Immunogenic DC ↑ Suppressive Treg ↓ IL-1β, IL-4, IL-6, IL-10, IL-23, IFN-γ, TNFα, TGFβ ↑ |
25 | |
| 1H8.2 | BALB/c | Ovalbumin-induced lung inflammation | Lymphocyte proliferation ↑ IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, TNFα, IFN-γ ↑ |
26 |
| RMT1-4 | C57BL/6 | Bleomycin-induced pulmonary fibrosis | IFN-γ production in NKT cell ↓ IL-4, IL-10, IL-13 ↑ |
27 |
| RMT1-10 | SJL | Autoimmune encephalomyelitis | Antigen specific T cell proliferation ↓ IL-17, IFN-γ ↓ IL-4, IL-10↑ |
24 |
| SJL | Autoimmune encephalomyelitis | IL-4, IL-10↑ IFN-γ ↓ | 25 | |
| C57BL/6 | Bleomycin-induced pulmonary fibrosis | IFN-γ production in NKT cell ↓ IL-10 ↑ | 27 | |
| C57BL/6 | Crescentic glomerulonephritis | Accumulation of Neutrophil, macrophage, CD4+ T cell ↓ Treg↑ IL-1β, IL-12, IL-17, TNFα, IFN-γ ↓ IL-4, IL-10↑ |
28 | |
| C57BL/6 | Islet allograft | IL-10 in B cell ↑ | 29 | |
| C57BL/6 | Lupus nephritis | CD4+ T cell proliferation ↓ Treg and B cell ↑ IL-2, IL-4, IL-17, IFN-γ ↓ TGFβ ↑ |
30 | |
| C57BL/6 | Cisplatin nephrotoxicity | Accumulation of CD4+ and CD8+ T cell ↓ IL-1β, IL-6, IFN-γ, TNFα ↓ IL-10 ↑ CXCL1, CXCL2, CXCL9, CXCL10, CCL2, CCL3, CCL5, ICAM1 ↓ |
31 | |
| C57BL/6 | Hepatic ischemia-reperfusion injury | Accumulation of Neutrophil, macrophage, T cell ↓ IL-6, TNFα, IL-1β, IFN-γ, CXCL-1, CXCL-2 ↓ |
32 | |
| BALB/c | Short ragweed pollen | Eosinophil infiltration ↓ IL-10, IL-13, and IFN-γ production ↑ |
33 | |
| BALB/c | Corneal allograft | CD4+ T cell proliferation ↓ Treg ↑ IL-4, IFN-γ ↓ TGFβ ↑ |
34 | |
| RMT1-17 | BALB/c | Immunization with ovalbumin | B cell proliferation ↑ IgG2b, IgG3 ↑ |
29 |
| 3A2.5 | BALB/c | Ovalbumin-induced lung inflammation | Lymphocyte proliferation ↓ IL-4, IL-5, IL-10↓ |
26 |
| 4A2.2 | BALB/c | Ovalbumin-induced lung inflammation | Lymphocyte proliferation ↓ IL-4, IL-5, IL-10, IL-13↓ |
26 |
| 222414 | BALB/c | Ovalbumin-induced asthma | Macrophage and eosinophils infiltration ↓ IL-4, IL-5, IL-10, IL-13 ↓ |
35 |
| BALB/c | Peanut-induced allergy | Lymphocyte proliferation ↓ IgE secretion from mast cells ↓ IL-4, IFN-γ ↓ |
36 | |
| C57BL/6 | Bleomycin-induced pulmonary fibrosis | IFN-γ production in NKT cell ↓ | 26 | |
| BALB/c | H1N1 influenza | Lymphocyte proliferation ↑ IL-4, IFN-γ production in CD4+ T cell ↑ |
37 |