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PTEN-deficient DLBCL cells were preferentially killed by schweinfurthin G (SG). (A) Plots of IC50 values of 10 DLBCL cell lines, normal human PBMC and fibroblasts IMR-90 upon SG treatment for 4 days. A PI3K inhibitor, BEZ-235, was included as a comparison. Cell lines with known PTEN mutation are indicated by asterisks. (B) Differential anti-proliferative effects of SG in DLBCL cells with wild type (wt) or mutant (mut) PTEN status. Protein expression of PTEN by the cell lines is shown.
