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The selective Fcγ receptors binding pattern of scFv-mFc measured by BIAcore. Gradient concentrations of IgG1 or scFv-mFc were injected over the CM5 sensor chip immobilized with FcγRI or FcγRIIIa. The kinetic profiles are shown. IgG1 binds to FcγRI (A) and FcγRIIIa (B) with affinities of 75 nM and 1.1 μM, respectively. scFv-mFc binds to FcγRI (C) with a affinity of 9.8 nM and has no detectable binding to FcγRIIIa (D).
