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. 2015 Jul 15;16(9):1353–1363. doi: 10.1080/15384047.2015.1070987

Figure 4.

Figure 4.

Glycolysis. (A) Data show consumption of β-D-(+)-glucose per 4 h in the supernatant growth medium after incubation with nifurtimox or growth medium alone normalized to the number of cells. Consumption of D-Glucose was significantly reduced for LA-N-1 (P = 0.0101), IMR-32 (P = 0.0057), LS (P = 0.0069) and SK-N-SH (P = 0.0078) after treatment with nifurtimox. Experiments were carried out in duplicates and represent one of 3 independent experiments with similar outcome. (B) Data show production of L-lactate per 4 h in the supernatant growth medium after incubation with nifurtimox or growth medium alone normalized to the number of cells. Production of lactate was significantly reduced for LA-N-1 (P = 0.0103), IMR-32 (P = 0.0214), LS (P = 0.0242) but not for SK-N-SH (P = 0.2753) after treatment with nifurtimox. Experiments were carried out in duplicates and represent one of 3 independent experiments with similar outcome. Data show mean ± standard error of the means. Significant changes vs. untreated tested via ANOVA indicate P < 0.05 (*) and P < 0.01 (**).