Table 2.
Levels of malondialdehyde (MDA)‚ superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH)‚ and myeloperoxidase (MPO) in heart tissue
| Groups | MDA (nmol/g tissue) | SOD (U/mg protein) | CAT (kU/mg protein) | GPx (IU/mg protein) | GSH (nmol/mL) | MPO (U/mg protein) |
|---|---|---|---|---|---|---|
| C1 | 7.43±2.05 | 63.96±2.46 | 23.48±2.32 | 7.65±1.74 | 0.56±0.09 | 24.21±5.22 |
| V1 | 5.56±1.47 | 57.51±8.78 | 28.30±7.39 | 7.23±2.57 | 0.46±0.08 | 26.70±9.10 |
| C2 | 7.23±1.53 | 59.95±7.16 | 22.48±3.03 | 7.84±1.87 | 0.62±0.06 | 24.21±5.35 |
| V2 | 14.95±3.80a,b | 58.19±17.77 | 10.22±3.14a,b | 4.09±0.97a,b | 0.34±0.07a,b | 46.21±7.83a,b |
Notes: Data are expressed as mean ± SD.
a
Significant P-values (P<0.05) vs chronic control group;
b
significant P-values (P<0.05) vs acute varenicline group.
Abbreviations: C1, control group for acute varenicline treatment (n=5); C2, control group for chronic varenicline treatment (n=5); V1, acute varenicline treatment group (n=12); V2, chronic varenicline treatment group (n=12); SD, standard deviation; vs, versus.