Table 4.
Results of semiquantitative histological assessment in all groups
| Parameters | C1 | V1 | C2 | V2 |
|---|---|---|---|---|
| Eosinophilic cytoplasm and pyknotic nuclei | 0 (0–0) | 1 (0–1)a | 0 (0–0) | 1.5 (1–2)b,c |
| Intracytoplasmic vacuoles | 0 (0–0) | 1 (0–2)a | 0 (0–0) | 1 (1–2)b,d |
| Interstitial congestion | 0 (0–1) | 1 (0–2)a | 0 (0–1) | 1 (0–2)b,c |
| Inflammatory cell infiltration | 0 (0–0) | 1 (0–2)a | 0 (0–0) | 1 (1–2)b,d |
Notes: Data are presented as score median (range).
a
Significant increase (P=0.0001) vs C1;
b
significant increase (P=0.0001) vs C2;
c
significant increase (P=0.0001) vs V1;
d
non-significant increase (P>0.05) vs V1.
Abbreviations: C1, control group for acute varenicline treatment (n=5); C2, control group for chronic varenicline treatment (n=5); V1, acute varenicline treatment group (n=12); V2, chronic varenicline treatment group (n=12); vs, versus.