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Inhibition on VEGF stimulated activation of KDR and VEGFR3. (A) Fruquintinib inhibited VEGF-A-stimulated KDR phosphorylation and downstream signaling in HUVEC. (b) Fruquintinib abrogated VEGF-A-stimulated KDR phosphorylation and downstream signaling in HEK-293-KDR cell line. (C) Fruquintinib suppressed VEGF-C stimulated VEGFR3 phosphorylation in VEGF-C-stimulated HLEC.
