Table 1.

PI3K inhibitor IC₅₀ selectivity profile- Summary of previously published biochemical selectivity for PI3K class I isoform inhibitors used in this study.

IC50(µM)	p110	p110	p110	p110	mTOR
Pan-PI3K inhibitor
ZSTK474	0.017	0.053	0.046	0.049	>10
Isoform-selective PI3K inhibitors
A66	0.032	>12.5	>1.25	3.48	>50
TGX-221	5	0.005	0.100	>35	>10
CAL-101	0.82	0.56	0.002	0.089	>1
IC488743	>20	1.2	0.005	—	—