Table 2.
GI50(µM) | A549 | H460 | H1975 | PC9 | H1650 |
---|---|---|---|---|---|
Pan-PI3K inhibitor | |||||
ZSTK474 | 0.33 | 0.15 | 0.21 | 0.40 | 0.69 |
Isoform-selective PI3K inhibitors | |||||
A66 | 15.64 | 8.10 | 1.74 | 23.31 | >200 |
TGX-221 | 24.19 | 26.78 | 21.88 | 120.5 | 50.14 |
CAL-101 | 22.09 | 10.66 | 10.85 | 131.6 | 62.10 |
IC488743 | 22.80 | 17.45 | 14.28 | 32.15 | 24.45 |