Table 2.

GI₅₀ values of PI3K inhibitors for NSCLC cell line. Each cell lines was treated with increasing concentrations of indicated PI3K inhibitors for 72 hr. Cell proliferations was determined by Alamar Blue viability assay. Non-linear curve fitting and GI₅₀ values were generated using Graphpad Prism.

GI50(µM)	A549	H460	H1975	PC9	H1650
Pan-PI3K inhibitor
ZSTK474	0.33	0.15	0.21	0.40	0.69
Isoform-selective PI3K inhibitors
A66	15.64	8.10	1.74	23.31	>200
TGX-221	24.19	26.78	21.88	120.5	50.14
CAL-101	22.09	10.66	10.85	131.6	62.10
IC488743	22.80	17.45	14.28	32.15	24.45