Table 3.
Differentially methylated regions (n = 30) identified using a Gaussian kernel (DMRcate) with methylation levels associated with trihalomethane exposure ((|Δβ|>0.05 and FDR<0.05) after adjusting for covariables (age, sex, first principal component and blood cells proportion)
| Associated gene symbol(s) | Genomic area(s) | Coordinates (hg19) | no. probes | Min P-value | Mean P-value | Max Δβ |
|---|---|---|---|---|---|---|
| chr8:125313573–125313940 | 3 | 3.06E-31 | 2.60E-28 | −0.05 | ||
| CEP97 | TSS1500,Body | chr3:101442954–101443851 | 4 | 5.44E-22 | 8.32E-13 | −0.05 |
| API5 | TSS1500,TSS200,1stExon,Body | chr11:43333145–43333782 | 7 | 1.13E-21 | 2.28E-19 | 0.05 |
| SNORD114–9,SNORD114–10,SNORD114–11 | TSS1500,TSS200 | chr14:101432120–101433601 | 4 | 3.67E-15 | 4.04E-12 | −0.06 |
| MYNN | TSS1500,TSS200,1stExon,5′UTR | chr3:169489583–169491183 | 8 | 1.23E-13 | 5.29E-08 | 0.07 |
| chr6:24360304–24360603 | 3 | 9.85E-06 | 1.77E-05 | 0.05 | ||
| chr1:19110734–19110922 | 2 | 1.28E-05 | 1.40E-05 | −0.15 | ||
| EXOC3L2 | 5′UTR,TSS200,TSS1500 | chr19:45737011–45738115 | 9 | 1.05E-04 | 5.98E-04 | 0.06 |
| PCDH15 | TSS200 | chr10:56561096–56561124 | 2 | 7.46E-04 | 7.48E-04 | 0.05 |
| DNHD1 | Body | chr11:6592066–6592745 | 3 | 1.22E-03 | 1.66E-03 | 0.06 |
| PCDHGA5,PCDHGA4,PCDHGA2,PCDHGB2,PCDHGA1,PCDHGB1,PCDHGA3 | TSS1500,Body,TSS200,1stExon | chr5:140743575–140744556 | 6 | 1.45E-03 | 7.12E-03 | 0.06 |
| C22orf27 | TSS1500,TSS200,Body | chr22:31317764–31318546 | 10 | 2.91E-03 | 4.95E-03 | −0.06 |
| GPX6 | 1stExon,5′UTR,TSS200 | chr6:28483537–28483691 | 2 | 3.66E-03 | 5.22E-03 | −0.07 |
| NXPH2 | TSS1500 | chr2:139538356–139539001 | 4 | 3.73E-03 | 1.13E-02 | 0.09 |
| SMAD3 | TSS1500 | chr15:67356310–67356942 | 3 | 5.66E-03 | 7.02E-03 | 0.09 |
| PRSS21 | TSS1500,Body | chr16:2866901–2868001 | 5 | 6.08E-03 | 1.30E-02 | −0.05 |
| chr8:599963–600488 | 4 | 6.68E-03 | 2.46E-02 | −0.07 | ||
| SLFN12 | 1stExon,5′UTR,TSS1500 | chr17:33759484–33759986 | 4 | 9.44E-03 | 1.97E-02 | −0.06 |
| LMTK3 | Body | chr19:49000743–49002477 | 6 | 1.18E-02 | 1.83E-02 | −0.06 |
| KCNMA1 | Body | chr10:79110632–79111034 | 2 | 1.19E-02 | 1.92E-02 | 0.06 |
| chr4:25090198–25090665 | 5 | 1.36E-02 | 1.93E-02 | −0.06 | ||
| chr2:47799165–47799268 | 2 | 1.44E-02 | 1.49E-02 | −0.05 | ||
| chr3:133502540–133503437 | 6 | 1.49E-02 | 2.07E-02 | 0.06 | ||
| KIF25 | Body | chr6:168435636–168435923 | 3 | 2.48E-02 | 2.54E-02 | −0.09 |
| DUSP22 | TSS200,1stExon,5′UTR,Body | chr6:291903–292596 | 5 | 2.89E-02 | 3.62E-02 | −0.08 |
| PPP4R2 | TSS1500 | chr3:73045556–73045686 | 2 | 2.94E-02 | 2.98E-02 | 0.07 |
| chr4:1512820–1513089 | 3 | 3.31E-02 | 3.78E-02 | −0.06 | ||
| C21orf56 | Body | chr21:47581558–47582049 | 2 | 3.33E-02 | 3.81E-02 | 0.07 |
| STK32C | Body | chr10:134045578–134046066 | 3 | 4.17E-02 | 4.66E-02 | 0.06 |
| chr8:125313573–125313940 | 3 | 3.06E-31 | 2.60E-28 | −0.05 |