Table 1.

Coded levels and measured responses for the 20 experiment formulation runs

No	A	B	C	Size (nm) (Y1)	EE% (Y2)	DL/% (Y3)
1	1:3	0.8	12	201.8	78.78	2.75
2	2:3	0.8	12	369.6	41.87	3.25
3	1:3	1.2	12	379.0	80.95	2.17
4	2:3	1.2	12	215.2	42.30	2.68
5	1:3	0.8	18	233.2	71.72	2.36
6	2:3	0.8	18	386.8	60.54	4.49
7	1:3	1.2	18	178.2	68.12	1.78
8	2:3	1.2	18	224.3	59.99	3.66
9	1:5	1.0	15	318.9	77.18	0.83
10	3:4	1.0	15	313.6	43.08	3.35
11	1:2	0.7	15	311.6	69.02	4.36
12	1:2	1.4	15	184.7	71.50	3.67
13	1:2	1.0	10	190.1	84.81	4.45
14	1:2	1.0	20	286.6	76.91	3.81
15	1:2	1.0	15	165.6	92.97	4.77
16	1:2	1.0	15	174.8	91.36	4.69
17	1:2	1.0	15	169.4	90.70	4.66
18	1:2	1.0	15	171.1	90.96	4.67
19	1:2	1.0	15	172.4	91.78	4.72
20	1:2	1.0	15	170.7	91.27	4.68

Notes: A, the ratio of silymarin to phospholipids; B, flow rate of solution; C, pressure.

Abbreviations: EE, entrapment efficiency; DL, drug loading.