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Comparison of the experimental and predicted values of SM-Lip-SEDS under predicted optimum conditions
| Measured responses | Predicted values | Experimental values | Bias (%) |
|---|---|---|---|
| Y1 (size) | 168.21 nm | 160.50 nm | 4.80 |
| Y2 (EE) | 92.29% | 91.38% | 0.99 |
| Y3 (DL) | 4.65% | 4.73% | −1.72 |
Note: Bias was calculated as (predicted value – observed value)/predicted value ×100%.
Abbreviations: SM, silymarin; SEDS, solution-enhanced dispersion by supercritical fluids; EE, encapsulation efficiency; DL, drug loading.
