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. 2015 Oct 22;10:6603–6614. doi: 10.2147/IJN.S85369

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© 2015 Boechat et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The effects of the MTX-LNC formulation on (A) TNF-α and (B) IL-6 production in PBMCs stimulated with PMA.

Notes: The cultures of stimulated PBMCs from healthy individuals showed reduction in TNF-α and IL-6 production by MTX-LNC. The TNF-α and IL-6 levels were lower in the MTX-LNC group and statistically different from those in the PMA-LNC (P=0.016 and P=0.018, respectively) and PMA-MTX groups (P=0.034 and P=0.045, respectively). For the analysis-of-variance multiple comparisons, Tukey’s test was applied. *P<0.05.

Abbreviations: IL-6, interleukin-6; LNC, blank lipid-core nanocapsules; MTX, methotrexate; MTX-LNC, MTX-loaded lipid-core nanocapsules; PBMCs, peripheral blood mononuclear cells; PMA, 4β-phorbol-12-myristate 13-acetate; PMA-LNC, 4-phorbol-12-myristate 13-acetate (PMA) plus LNC; TNF-α, tumor necrosis factor-alpha.