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. 2014 Nov 1;6(6):1598–1607. doi: 10.4161/mabs.36089

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

© Feifan Yu, Lindvi Gudmundsdotter, Anastassja Akal, Elin Gunneriusson, Fredrik Frejd, and Per-Åke Nygren

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 4. — HUVEC cell assay (trans-signaling). Results from an analysis of the ability of affibody variants Z_{IL-6_4}, Z_{IL-6_8}, Z_{IL-6_12}, Z_{IL-6_13} and Z_{IL-6_15}, expressed as Z-ABD fusion proteins, or the mAb tocilizumab, to block the IL-6 triggered secretion of MCP-1 from HUVEC cells.