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. 2014 Nov 1;6(6):1631–1637. doi: 10.4161/mabs.36107

Table 1.

Anti-DLL4 pharmacokinetic parameters in non-tumor bearing athymic nude mice

Parameter 0.2 mg/kg 2 mg/kg 20 mg/kg
Measured dose (mg/kg) 0.11 2.1 16.6
Cmax (μg/mL) 5.0 32.5 524
AUCinf (day•μg/mL) 2.0 42 2014
CLtot (mL/day/kg) 58 49 8.2
Vss (mL/kg) 24 89 53