Figure 1.

Dex inhibits cell proliferation in CCRF-CEM, Raji and U-937 cells. (A) CCRF-CEM, Raji and U-937 cells were treated with increasing concentrations of Dex for 24 and 48 h, and cell viability was determined by WST-8 assay. Error bars represent the standard errors of 3 independent experiments. (Dex vs. control: *P < 0.05, **P < 0.01) (B) Cells were treated with the indicated concentrations of Dex for the indicated times, and the percentage of dead cells was measured by trypan blue exclusion assay. (Dex versus control: *P < 0.05, **P < 0.01, ***P < 0.001) (C) Cells were treated with or without 1 μM Dex for 48 h. The percentage of apoptotic cells was determined by Annexin V-PI staining followed by FACS analysis. Values represent the means ± SD of 3 independent experiments. (Dex vs. control: **P < 0.01)