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. 2015 Feb 3;10(4):282–292. doi: 10.1080/15592294.2015.1006505

Table 3.

Odds ratios and 95% confidence intervals for renal cell carcinoma risk and LINE1 %5mC

PLCO1
   ATBC2
    Case
 Control
       Case
 Control
  
Characteristic   N N OR 95%CI P3 Characteristic   N N OR 95%CI P3
Methylation Quartiles3             Methylation Quartiles4            
Q1   56 114 1.00 (ref.)     Q1   40 145 1.00 (ref.)    
Q2   47 114 0.87 (0.52-1.45) 0.59 Q2   36 146 1.13 (0.63-2.02) 0.69
Q3   49 102 1.18 (0.71-1.96) 0.51 Q3   57 141 1.83 (1.06-3.18) 0.03
Q4   63 106 1.37 (0.84-2.21) 0.20 Q4   58 143 1.78 (1.00-3.19) 0.05
P-trend           0.12 P-trend           0.02
                           
Methylation Median5             Methylation Median6            
M1   103 228 1.00 (ref.)     M1   76 291 1.00 (ref.)    
M2   112 208 1.37 (0.96-1.95) 0.08 M2   115 284 1.31 (1.07-1.60) 0.01
                           
Gender             See above            
Male M1 63 115 1.00 (ref.)                  
  M2 76 136 1.54 (1.00-2.39) 0.053              
Female M1 40 73 1.00 (ref.)                  
  M2 36 72 1.16 (0.61-2.21) 0.65              
P-int           0.42              
Age at blood draw (years)                          
55-64 M1 36 92 1.00 (ref.)     53-64 M1 66 250 1.00 (ref.)    
  M2 50 84 2.17 (1.17-4.01) 0.01   M2 72 170 1.33 (1.05-1.67) 0.02
65-79 M1 67 136 1.00 (ref.)     65–76 M1 10 41 1.00 (ref.)    
  M2 62 124 1.16 (0.73–1.83) 0.53   M2 43 114 1.08 (0.65–1.79) 0.76
P-int           0.18 P-int           0.82
<4 M1 75 154 1.00 (ref.)     <4 M1 24 100 1.00 (ref.)    
  M2 75 146 1.17 (0.76–1.79) 0.48   M2 40 102 1.23 (0.83–1.82) 0.31
5–17 M1 28 74 1.00 (ref.)     5–17 M1 52 191 1.00 (ref.)    
  M2 37 62 2.15 (1.09–4.25) 0.03   M2 75 182 1.41 (1.10–1.82) 0.01
P-int           0.19 P-int           0.55
History of Hypertension                          
No M1 60 152 1.00 (ref.)     No M1 64 243 1.00 (ref.)    
  M2 64 152 1.07 (0.68–1.68) 0.77   M2 80 234 1.28 (1.01–1.61) 0.04
Yes M1 42 75 1.00 (ref.)     Yes M1 12 48 1.00 (ref.)    
  M2 48 55 2.08 (1.14–3.80) 0.02   M2 35 50 1.52 (0.90–2.56) 0.11
P-int           0.10 P-int           0.19
BMI (kg/m2)                          
16.7–<25 M1 22 63 1.00 (ref.)     17.6–<25 M1 21 89 1.00 (ref.)    
  M2 23 60 1.29 (0.58–2.90) 0.53   M2 36 122 1.03 (0.70–1.52) 0.87
25 to <30 M1 39 110 1.00 (ref.)     25 to <30 M1 43 149 1.00 (ref.)    
  M2 51 102 1.50 (0.87–2.58) 0.14   M2 54 131 1.31 (0.97–1.77) 0.80
30–62.1 M1 42 55 1.00 (ref.)     30–40.4 M1 12 53 1.00 (ref.)    
  M2 38 46 1.15 (0.60–2.20) 0.67   M2 25 31 3.27 (1.30–8.23) 0.01
P-int           0.65 P-int           0.10
Ever/Never Smoking             NA            
Never M1 54 92 1.00 (ref.)                  
  M2 41 98 0.81 (0.47–1.39) 0.44              
Ever M1 49 136 1.00 (ref.)                  
  M2 71 110 2.15 (1.33–3.48) 0.002              
P-int           0.01              
Pack-Years of Smoking                          
1–40 M1 32 90 1.00 (ref.)     1–40 M1 51 222 1.00 (ref.)    
  M2 44 68 2.00 (1.08–3.69) 0.03   M2 72 201 1.34 (1.03–1.73) 0.03
41–200 M1 17 46 1.00 (ref.)     41–113 M1 25 69 1.00 (ref.)    
  M2 27 42 2.62 (1.08–6.33) 0.03   M2 43 83 1.35 (0.88–2.06) 0.17
P-int           0.76 P-int           0.87
Family History of Cancer                          
No M1 47 114 1.00 (ref.)     No M1 38 135 1.00 (ref.)    
  M2 54 96 1.81 (1.06–3.07) 0.03   M2 49 115 1.34 (0.99–1.82) 0.06
Yes M1 56 114 1.00 (ref.)     Yes M1 29 129 1.00 (ref.)    
  M2 58 112 1.06 (0.64–1.75) 0.83   M2 50 122 1.36 (0.99–1.88) 0.06
P-int           0.18 P-int           0.80

Abbreviations: ATBC- Alpha-Tocopherol, Beta-Carotene Cancer Prevenetion Cohort; BMI- body mass index; CI- confidence interval; M- median; N- number; NA- not applicable; OR- odds ratio; P-int- p-interaction; PLCO- Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; Q- quartiles; ref.- reference.

Data on Family History of Cancer missing from 25 cases and 74 controls in ATBC.

Data on hypertension missing from 1 case and 2 controls, data on diabetes status missing from 2 controls, and data on pack years of smoking missing from 1 case and 7 controls in PLCO.

1

PLCO adjusted for hypertention, BMI, pack-years of smoking, age at blood draw, study center, dietary alcohol intake, family history of cancer, and sex

2

ATBC adjusted for hypertention, BMI, pack-years of smoking, age at blood draw, study center, dietary alcohol intake, family history of cancer, and intervention arm

3

Quartile distribution for PLCO males: 73.60 to <76.50%; 76.50% to <77.20%; 77.20% to <78.00%; 78.00 to 80.60; females: 72.00 to <75.80%; 75.80% to <76.70%; 76.70% to <77.45%; 77.45% to 79.30.

4

Quartile distribution for ATBC: 75.23 to <77.96%; 77.96% to <78.60%; 78.60% to <79.60%; 79.60 to 83.80.

5

Median distribution for PLCO males: 73.60 to <77.20%; 77.20% to 80.60; females: 72.00 to <76.70%; 76.70% to 79.30.

6

Median distribution for ATBC: 75.23 to <78.60%; 78.60% to 83.80.