Table 4.

Odds ratios and 95% confidence intervals for renal cell carcinoma risk and LINE1 %5mC by gender and smoking status in PLCO

PLCO1
	Never Smokers					Ever Smokers
Sex	Cases	Controls	OR	95%CI	P3	Cases	Controls	OR	95%CI	P3
MALES
Quartile 1 (Q1)	15	25	1.00 (ref.)			22	54	1.00 (ref.)
Quartile 2 (Q2)	14	27	1.06	(0.35–3.18)	0.92	12	49	0.60	(0.24–1.46)	0.26
Quartile 3 (Q3)	8	28	0.68	(0.20–2.30)	0.54	23	38	1.85	(0.84–4.09)	0.13
Quartile 4 (Q4)	12	31	0.87	(0.30–2.51)	0.80	33	39	2.34	(1.10–4.97)	0.03
P-trend					0.66					0.01
P-Int										0.03
< Median (M1)	29	52	1.00 (ref.)			34	103	1.00 (ref.)
> Median (M2)	20	59	0.77	(0.35–1.69)	0.52	56	77	2.60	(1.46–4.63)	0.001
P-Int										0.01
FEMALES
Quartile 1 (Q1)	12	18	1.00 (ref.)			7	17	1.00 (ref.)
Quartile 2 (Q2)	13	22	0.99	(0.30–3.29)	0.99	8	16	0.66	(0.12–3.52)	0.62
Quartile 3 (Q3)	10	19	0.80	(0.21–2.99)	0.74	8	17	1.49	(0.31–7.15)	0.62
Quartile 4 (Q4)	11	20	0.90	(0.26–3.10)	0.87	7	16	1.43	(0.28–7.40)	0.67
P-trend					0.79					0.49
P-Int										0.82
< Median (M1)	25	40	1.00 (ref.)			15	33	1.00 (ref.)
> Median (M2)	21	39	0.86	(0.36–2.04)	0.73	15	33	1.78	(0.56–5.68)	0.33
P-Int										0.47

Abbreviations: BMI- body mass index; CI- confidence interval; M- median; OR- odds ratio; P-int- p-interaction; PLCO- Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; Q- quartiles; ref.- reference.

Quartile distribution for PLCO males: 73.60 to <76.50%; 76.50% to <77.20%; 77.20% to <78.00%; 78.00 to 80.60; females: 72.00 to <75.80%; 75.80% to <76.70%; 76.70% to <77.45%; 77.45% to 79.30.

¹PLCO adjusted for hypertention, BMI, age at blood draw, study center, dietary alcohol intake, family history of cancer. ²χ² P-value