Table 5.

Performance of a panel of CpG sites for detecting early-stage OSCC

Rank†	Panel of CpG sites	Specificity	Sensitivity	AUC
2	KDR_E79_F + GSTM2_E153_F + MT1A_P49_R	86.7%	100.0%	0.933
2	FLT4_E206_F + GSTM2_E153_F + MT1A_P49_R	86.7%	100.0%	0.933
2	GSTM2_E153_F + MT1A_P49_R + NPY_E31_R	86.7%	100.0%	0.933
4	FLT4_E206_F	100.0%	81.3%	0.906
6	KDR_E79_F + TFPI2_P9_F	100.0%	81.3%	0.906
6	FLT4_E206_F + KDR_E79_F	100.0%	81.3%	0.906
6	FLT4_E206_F + TFPI2_P9_F	100.0%	81.3%	0.906
8	FLT4_E206_F + KDR_E79_F + TFPI2_P9_F	100.0%	81.3%	0.906
10.5	GSTM2_E153_F + NPY_E31_R	86.7%	93.8%	0.902
10.5	KDR_E79_F + GSTM2_E153_F	86.7%	93.8%	0.902
10.5	FLT4_E206_F + GSTM2_E153_F	86.7%	93.8%	0.902
10.5	GSTM2_E153_F + MT1A_P49_R	86.7%	93.8%	0.902
20	FLT4_E206_F + GSTM2_E153_F + EPHA7_E6_F	86.7%	93.8%	0.902
20	FLT4_E206_F + GSTM2_E153_F + ADCYAP1_P455_R	86.7%	93.8%	0.902
20	FLT4_E206_F + TFPI2_P9_F + GSTM2_E153_F	86.7%	93.8%	0.902
20	TFPI2_P9_F + GSTM2_E153_F + MT1A_P49_R	86.7%	93.8%	0.902
20	KDR_E79_F + TFPI2_P9_F + GSTM2_E153_F	86.7%	93.8%	0.902
20	GSTM2_E153_F + MT1A_P49_R + EPHA7_E6_F	86.7%	93.8%	0.902
20	GSTM2_E153_F + NPY_E31_R + EPHA7_E6_F	86.7%	93.8%	0.902
20	KDR_E79_F + GSTM2_E153_F + NPY_E31_R	86.7%	93.8%	0.902
20	FLT4_E206_F + GSTM2_E153_F + NPY_E31_R	86.7%	93.8%	0.902
20	FLT4_E206_F + KDR_E79_F + GSTM2_E153_F	86.7%	93.8%	0.902
20	GSTM2_E153_F + NPY_E31_R + ADCYAP1_P455_R	86.7%	93.8%	0.902
20	KDR_E79_F + GSTM2_E153_F + ADCYAP1_P455_R	86.7%	93.8%	0.902
20	KDR_E79_F + GSTM2_E153_F + EPHA7_E6_F	86.7%	93.8%	0.902
20	GSTM2_E153_F + MT1A_P49_R + ADCYAP1_P455_R	86.7%	93.8%	0.902
20	TFPI2_P9_F + GSTM2_E153_F + NPY_E31_R	86.7%	93.8%	0.902

^†ranked by AUC and then the number of CpG sites in each combination (average rank is assigned if tied).