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. 2014 Dec 18;7(1):120–128. doi: 10.4161/19420862.2015.989028

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© 2015 The Author(s). Taylor & Francis Group, LLC

© Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda, Miho Funaki, Kazutaka Yoshihashi, Takehisa Kitazawa, Atsushi Muto, Tetsuo Kojima, Satoshi Nakamura, and Kunihiro Hattori

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 4. — Effect of upper hinge sequence on FVIII-mimetic activity. (A) The FVIII-mimetic activity of the parent IgG₄ antibody with the YGPP sequence (black circles), the IgG₄-PGPP variant (red squares), and the IgG₄-PPPP variant (blue diamonds) is shown. (B) The FVIII-mimetic activity of the parent IgG₄(YGPP) antibody (black circles), the asymmetric upper hinge variants: Qch-PPPP (green triangles), and Jch-PPPP (purple circles), is shown.