Table 2.

Univariate and multivariate analysis of factors associated with survival time of patients with non-small cell cancer

Clinical variable	Case number	HR (95% CI)	P Value
Univariate analysis
miR-145 (Unmethylation vs. Methylation)	43/79	1.851(1.355–2.528)	<0.001
Age ( >60 vs. ≤60)	67/55	1.034(0.777–1.375)	0.819
Gender (Male vs. Female)	78/44	1.202(0.896–1.613)	0.220
Histological type (SqCC vs A vs. Other)	36/71/15	1.087(0.847–1.394)	0.513
Distant metastasis
(M1 vs. M0)	24/98	5.280(3.552–7.850)	<0.001
T factor (T3 + T4 vs. T1 + T2)	41/71	1.249(0.940–1.660)	0.126
Lymph node (N2 + N3 vs. N0 + N1)	64/58	5.466(3.942–7.580)	<0.001
Clinical stage ( = 3/* ROMAN III + = 4/* ROMAN IV vs.  = 1/* ROMAN I + = 2/* ROMAN II)	66/56	7.424(5.228–10.541)	<0.001
Differentiation
(Moderate + high vs. Low)	57/65	2.006(1.500–2.684)	<0.001
Multivariate analysis
miR-145 (Unmethylation vs. Methylation)	43/79	0.414(0.297–0.578)	<0.001
Differentiation
(Moderate + high vs. Low)	57/65	1.295(0.928–1.806)	0.128
Distant metastasis
(M1 vs. M0)	24/98	3.877(2.515–5.976)	<0.001
Lymph node (N2 + N3 vs. N0 + N1)	64/58	1.270(0.703–2.297)	0.428
Clinical stage ( = 3/* ROMAN III + = 4/* ROMAN IV
vs. = 1/* ROMAN I + = 2/* ROMAN II)	66/56	6.171(3.248–11.726)	<0.001