Table 2.
Median survival (days) of athymic mice bearing i.p. LS-174T xenografts following i.p. administration of 212Pb-cetuximab and chemotherapeutics
| Radioimmunotherapy |
|||
|---|---|---|---|
| Chemotherapeutic | None | Cetuximab | HuIgG |
| None | 24 | 174 (7.3) | 24 (1.0) |
| Gemcitabine | 24 (1.0)a | 283 (11.8) | 49 (2.0) |
| Carboplatin | 31 (1.3) | 80 (3.3) | 43 (1.8) |
aThe values in parentheses are the therapeutic indices (median survival of the treatment group divided by the median survival of untreated group). The gemcitabine and carboplatin were injected 24 h prior to 212Pb-RIT administration.