Table 2.

Brain areas showing brain perfusion changes at rest in unmedicated and medicated patients with MDD (n=43) compared to controls (n=29)^*

	SPM analysis						BPM analysis
Comparison	Region	x	y	z	Z	No. of voxels	Region	x	y	z	Z	No. of voxels
Controls > patients	Right cuneus	16	−90	8	4.57	2703	Right cuneus	15	−90	8	4.55	2725
	Right parahippocampal gyrus	24	−24	−16	3.21		Right parahippocampal gyrus	22	−26	−14	3.45
	Left parahippocampal gyrus	−18	−26	−18	3.54	449	Left parahippocampal gyrus	−18	−26	−18	3.40	389
	Left anterior cingulate	−8	26	−6	3.44	214	Left anterior cingulate	−8	28	−6	3.48	238
Patients > controls	Right inferior parietal lobule	34	−62	44	4.23	1955	Right inferior parietal lobule	34	−62	44	4.31	1933
	Right middle temporal gyrus	52	−45	8	3.43		Right middle temporal gyrus	52	−45	8	3.47
	Right middle frontal gyrus	20	28	46	4.07	2905	Right middle frontal gyrus	20	28	46	4.09	3242
	Right medial frontal gyrus	10	25	44	3.91		Right superior frontal gyrus	25	32	38	3.95
	Right superior frontal gyrus	8	30	48	3.91		Right medial frontal gyrus	8	25	44	3.72
	Right middle frontal gyrus	38	15	45	3.72		Right middle frontal gyrus	38	15	45	3.53
	Left middle frontal gyrus	−24	20	50	3.25		Right middle frontal gyrus	40	−2	52	3.47
							Right superior frontal gyrus	20	55	10	3.38
							Left middle frontal gyrus	−24	20	50	3.22
	Right lentiform nucleus	20	10	−2	4.03	848	Right lentiform nucleus	22	10	−4	4.30	896
	Right caudate	15	10	12	3.58		Right caudate	16	10	12	3.55

BPM = Biological Parametric Mapping; MDD = major depressive disorder; SPM = Statistical Parametric Mapping.

^*Results of second-level t tests (standard SPM8 analysis) and analysis of covariance (BPM analysis), p < 0.005 uncorrected at the voxel level, p < 0.05 corrected for spatial extent.