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. 2014 Nov 3;6(6):1394–1401. doi: 10.4161/mabs.34377

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

© Andrea LJ Marschall, Frank N Single, Katrin Schlarmann, Andreas Bosio, Nina Strebe, Joop van den Heuvel, André Frenzel, and Stefan Dübel

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Analysis of B-cells in the peripheral blood. The fraction of immature B-cells (IgM⁺ IgD⁻) is increased in animals that are heterozygous or homozygous for the ER-intrabody gene. Mature B-cells (IgM⁺ IgD⁺) in turn are decreased in ER-intrabody mice compared to controls. In 3 independent experiments the difference between ER-intrabody mice and controls was observed to be most pronounced in homozygous iER-VCAM1 mice.