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. 2015 Mar 18;16(5):690–698. doi: 10.1080/15384047.2015.1026508

Figure 3.

Figure 3.

Computer tomography (CT), CTC images and EpCAM immunostaining of CRC tumors. EpCAM is consistently expressed in CRC primary tumors, also in patients that have no CTCs detectable by EpCAM-based CellSearch® system. Shown are: mean CTC numbers (±SEM), the actual liver/tumor volume ratio, a CTC (CellSearch® system qualifies a cell as a CTC if it has an evident nucleus by DAPI and if it is EpCAM+, cytokeratin 8/18/19+, and CD45-), (A) CT scan of a patient with a high tumor/liver ratio (≥30%) and high baseline CTCs (≥3), (B) EpCAM immunostaining with a monoclonal antibody (BerEP4) and peroxidase method of the respective CRC primary tumor, (C) CT scan of a patient with a low high tumor/liver ratio (<30%) zero baseline CTCs, and (D) EpCAM immunostaining of the respective CRC primary tumor.