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. 2015 Mar 12;7(3):605–619. doi: 10.1080/19420862.2015.1026501

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© 2015 AbbVie Inc.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — Potency determination of mAb X3 on human and cynomolgus IL-1α. The MRC-5 cell line produces IL-8 in response to stimulation with both human and cynomolgus IL-1α and IL-1β. In this potency assay, MRC-5 cells were stimulated with 3 pM of either human (•) or cynomolgus (▪) IL-1α in the presence of increasing concentrations of the IL-1α-specific mAb X3.